原文翻译自文章:New insights into the mechanisms of venous thrombosis. https://pubmed.ncbi.nlm.nih.gov/22751108/ 静脉血栓形成是工业化国家发病和死亡的一个主要原因,特别是在老年人中。静脉血栓形成的主要危险因素是改变血流,激活内皮细胞,增加血液凝固。然而,触发大静脉凝血的确切机制尚未完全阐明。因瓣囊窦有缺氧的倾向故为最常见的血栓起始部位。内皮细胞在缺氧或炎症刺激下活化会导致粘附受体的表面表达,从而促进循环中的白细胞和微囊泡的结合。随后激活的白细胞诱导表达有效的促凝蛋白组织因子,引发血栓形成。了解静脉血栓形成的机制可以推动新治疗的发展。
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